Diffuse BioDiffuse Bio

Machine Learning Research Engineer

Added 2 months ago

Description

At Diffuse Bio we’re building generative AI for protein therapeutics. Our team has been behind breakthroughs in AI protein design for the past 6 years, including the first experimental validation of AI-generated proteins and diffusion models for protein structure and sequence. We’ve built the first entirely AI computational nanobody design platform and are testing designs in lab now. 

Our goal is to build AI systems that can design protein therapeutics for the most challenging and high-value targets. We see enormous potential for AI to revolutionize drug discovery and expand the set of diseases we can treat. 

We are looking for candidates who are excited about the opportunity to join the founding team and play an expanding role in the company.

The role:

  • Extend and scale Diffuse’s in-house deep generative modeling toolkit for downstream applications in molecular design.

  • Thoughtfully execute deep learning experiments to improve performance of models or develop new functionality (e.g. loop engineering, structure prediction of protein-protein complexes).

  • Work closely with software engineers to build systems for efficient training and deployment of deep learning models.

Ideal background:

  • Self-starter who enjoys working on tough scientific problems and is results-driven.

  • Able to think critically, methodically, and creatively about experiments.

  • Proficient in Python.

  • Experience working with deep learning frameworks (e.g., PyTorch).

  • 3+ years of industry experience in a data science or engineering position.

  • Track record of impressive work in industry/academia centered on ML / deep learning.

  • Graduate degree in math, CS, stats, bioengineering, comp bio, or a related field (not a hard requirement for exceptional candidates).

  • Is located in the Bay Area (remote work is an option for exceptional candidates).

Pluses:

  • Knowledge of physics, math, molecular biology, chemistry, etc.

  • Previous work on ML applied to problems in structural biology or molecular design.

  • Strong publication record.

What we offer:

  • The opportunity to join the founding team and play a critical and expanding role in shaping the company.

  • The opportunity to work on cutting-edge AI with leading researchers from top institutions.

Company

Diffuse Bio develops AI tools for designing and optimizing protein binders and therapeutics. Their product offerings include DiffuseSandbox, an end-to-end platform for protein design; RamaX Opt, marketed as ultra-fast affinity maturation; and RamaX, a platform for high-throughput binder screening at scale. The company positions its tools to enable researchers to design novel protein binders in minutes on a laptop rather than weeks in a lab, with scalable cloud workflows. The company’s content highlights research publications and media coverage, including Nature publications and NYT features. Headquarters are in San Carlos, California.

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